Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells
نویسندگان
چکیده
منابع مشابه
Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling.
Studies in both humans and rodents have found that insulin(+) cells appear within or near ducts of the adult pancreas, particularly following damage or disease, suggesting that these insulin(+) cells arise de novo from ductal epithelium. We have found that insulin(+) cells are continuous with duct cells in the epithelium that makes up the hyperplastic ducts of both chronic pancreatitis and panc...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2016
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2015-1175